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1d7m

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Template:STRUCTURE 1d7m

Contents

COILED-COIL DIMERIZATION DOMAIN FROM CORTEXILLIN I

Template:ABSTRACT PUBMED 10745004

Function

[CTXA_DICDI] Acting-bundling protein. When linked to F-actin the actin filaments form preferentially anti-parallel bundles that associate into meshworks. Plays a major role in cytokinesis. Negatively regulates cortical localization of rapgap1.[1]

About this Structure

1d7m is a 2 chain structure with sequence from Dictyostelium discoideum. Full crystallographic information is available from OCA.

Reference

  • Burkhard P, Kammerer RA, Steinmetz MO, Bourenkov GP, Aebi U. The coiled-coil trigger site of the rod domain of cortexillin I unveils a distinct network of interhelical and intrahelical salt bridges. Structure. 2000 Mar 15;8(3):223-30. PMID:10745004
  1. ↑ Jeon TJ, Lee DJ, Lee S, Weeks G, Firtel RA. Regulation of Rap1 activity by RapGAP1 controls cell adhesion at the front of chemotaxing cells. J Cell Biol. 2007 Dec 3;179(5):833-43. Epub 2007 Nov 26. PMID:18039932 doi:jcb.200705068

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