1a50

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Template:STRUCTURE 1a50

Contents 1 CRYSTAL STRUCTURE OF WILD-TYPE TRYPTOPHAN SYNTHASE COMPLEXED WITH 5-FLUOROINDOLE PROPANOL PHOSPHATE 2 Function 3 About this Structure 4 Reference

CRYSTAL STRUCTURE OF WILD-TYPE TRYPTOPHAN SYNTHASE COMPLEXED WITH 5-FLUOROINDOLE PROPANOL PHOSPHATE

Template:ABSTRACT PUBMED 9548921

Function

[TRPA_SALTY] The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. [TRPB_SALTY] The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

About this Structure

1a50 is a 2 chain structure with sequence from Salmonella enterica subsp. enterica serovar typhimurium. Full crystallographic information is available from OCA.

Reference

• Schneider TR, Gerhardt E, Lee M, Liang PH, Anderson KS, Schlichting I. Loop closure and intersubunit communication in tryptophan synthase. Biochemistry. 1998 Apr 21;37(16):5394-406. PMID:9548921 doi:http://dx.doi.org/10.1021/bi9728957