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1bj0

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Template:STRUCTURE 1bj0

Contents

TETRACYCLINE CHELATED MG2+-ION INITIATES HELIX UNWINDING FOR TET REPRESSOR INDUCTION

Template:ABSTRACT PUBMED 9890898

Function

[TETR4_ECOLI] TetR is the repressor of the tetracycline resistance element; its N-terminal region forms a helix-turn-helix structure and binds DNA. Binding of tetracycline to TetR reduces the repressor affinity for the tetracycline resistance gene (tetA) promoter operator sites.

About this Structure

1bj0 is a 1 chain structure with sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

  • Orth P, Saenger W, Hinrichs W. Tetracycline-chelated Mg2+ ion initiates helix unwinding in Tet repressor induction. Biochemistry. 1999 Jan 5;38(1):191-8. PMID:9890898 doi:10.1021/bi9816610

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OCA

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