3f02

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Template:STRUCTURE 3f02

Contents

Cleaved human neuroserpin

Template:ABSTRACT PUBMED 19265707

Disease

[NEUS_HUMAN] Familial encephalopathy with neuroserpin inclusion bodies. The disease is caused by mutations affecting the gene represented in this entry.

Function

[NEUS_HUMAN] Serine protease inhibitor that inhibits plasminogen activators and plasmin but not thrombin. May be involved in the formation or reorganization of synaptic connections as well as for synaptic plasticity in the adult nervous system. May protect neurons from cell damage by tissue-type plasminogen activator.

About this Structure

3f02 is a 4 chain structure with sequence from Human. Full crystallographic information is available from OCA.

Reference

  • Ricagno S, Caccia S, Sorrentino G, Antonini G, Bolognesi M. Human neuroserpin: structure and time-dependent inhibition. J Mol Biol. 2009 Apr 24;388(1):109-21. Epub 2009 Mar 2. PMID:19265707 doi:10.1016/j.jmb.2009.02.056

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