3sw8

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Template:STRUCTURE 3sw8

Contents

Strep Peptide Deformylase with a time dependent dichlorobenzamide-reverse hydroxamic acid

Template:ABSTRACT PUBMED 21711014

Function

[Q939R9_STREE] Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity).[HAMAP-Rule:MF_00163]

About this Structure

3sw8 is a 1 chain structure with sequence from "diplococcus_pneumoniae"_(klein_1884)_weichselbaum_1886 "diplococcus pneumoniae" (klein 1884) weichselbaum 1886. Full crystallographic information is available from OCA.

Reference

  • Totoritis R, Duraiswami C, Taylor AN, Kerrigan JJ, Campobasso N, Ward P, King BW, Murray-Thompson MF, Jones AD, Van Aller G, Aubart KM, Zalacain M, Thrall SH, Meek TD, Schwartz B. Understanding the Origins of Time Dependent Inhibition by Polypeptide Deformylase Inhibitors. Biochemistry. 2011 Jun 28. PMID:21711014 doi:10.1021/bi200655g

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