4k51

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Template:STRUCTURE 4k51

Contents

Crystal Structure of the PCI domain of eIF3a

Template:ABSTRACT PUBMED 24423867

Function

[EIF3A_YEAST] Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.[1] [2] [3] [4]

About this Structure

4k51 is a 2 chain structure with sequence from Baker's yeast. Full crystallographic information is available from OCA.

Reference

  • Khoshnevis S, Gunisova S, Vlckova V, Kouba T, Neumann P, Beznoskova P, Ficner R, Valasek LS. Structural integrity of the PCI domain of eIF3a/TIF32 is required for mRNA recruitment to the 43S pre-initiation complexes. Nucleic Acids Res. 2014 Jan 13. PMID:24423867 doi:http://dx.doi.org/10.1093/nar/gkt1369
  1. ↑ Valasek L, Trachsel H, Hasek J, Ruis H. Rpg1, the Saccharomyces cerevisiae homologue of the largest subunit of mammalian translation initiation factor 3, is required for translational activity. J Biol Chem. 1998 Aug 14;273(33):21253-60. PMID:9694884
  2. ↑ Phan L, Schoenfeld LW, Valasek L, Nielsen KH, Hinnebusch AG. A subcomplex of three eIF3 subunits binds eIF1 and eIF5 and stimulates ribosome binding of mRNA and tRNA(i)Met. EMBO J. 2001 Jun 1;20(11):2954-65. PMID:11387228 doi:http://dx.doi.org/10.1093/emboj/20.11.2954
  3. ↑ Valasek L, Mathew AA, Shin BS, Nielsen KH, Szamecz B, Hinnebusch AG. The yeast eIF3 subunits TIF32/a, NIP1/c, and eIF5 make critical connections with the 40S ribosome in vivo. Genes Dev. 2003 Mar 15;17(6):786-99. PMID:12651896 doi:http://dx.doi.org/10.1101/gad.1065403
  4. ↑ Szamecz B, Rutkai E, Cuchalova L, Munzarova V, Herrmannova A, Nielsen KH, Burela L, Hinnebusch AG, Valasek L. eIF3a cooperates with sequences 5' of uORF1 to promote resumption of scanning by post-termination ribosomes for reinitiation on GCN4 mRNA. Genes Dev. 2008 Sep 1;22(17):2414-25. doi: 10.1101/gad.480508. PMID:18765792 doi:http://dx.doi.org/10.1101/gad.480508

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