1xqo

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Template:STRUCTURE 1xqo

Contents

Crystal structure of native Pa-AGOG, 8-oxoguanine DNA glycosylase from Pyrobaculum aerophilum

Template:ABSTRACT PUBMED 15642264

Function

[AGOG_PYRAE] DNA repair enzyme that is part of the base excision repair (BER) pathway; protects from oxidative damage by removing the major product of DNA oxidation, 8-oxoguanine (GO), from single- and double-stranded DNA substrates.[1]

About this Structure

1xqo is a 1 chain structure with sequence from Atcc 51768. Full crystallographic information is available from OCA.

See Also

Reference

  • Lingaraju GM, Sartori AA, Kostrewa D, Prota AE, Jiricny J, Winkler FK. A DNA glycosylase from Pyrobaculum aerophilum with an 8-oxoguanine binding mode and a noncanonical helix-hairpin-helix structure. Structure. 2005 Jan;13(1):87-98. PMID:15642264 doi:10.1016/j.str.2004.10.011
  1. ↑ Sartori AA, Lingaraju GM, Hunziker P, Winkler FK, Jiricny J. Pa-AGOG, the founding member of a new family of archaeal 8-oxoguanine DNA-glycosylases. Nucleic Acids Res. 2004 Dec 16;32(22):6531-9. Print 2004. PMID:15604455 doi:http://dx.doi.org/10.1093/nar/gkh995

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