Proteinase
From Proteopedia
Proteinase (PRO) are enzymes which hydrolyze peptide bonds. They are classified by the amino acid site of their cleavage or by the pH at which they are active. PRO B is a serine protease. For more details on PRO B see Streptomyces griseus proteinase B. PRO A is a carboxylproteinase. Proteinase K (PRO) is a serine protease which cleaves proteins preferentially after hydrophobic residues. Calcium ions contribute to the stability of the enzyme. PRO is active over a wide pH range and is used in molecular biology to inactivate nucleases from preparations of DNA or RNA. PRO is used in the partial proteolysis of lactoferrin into its N- and C-lobe. The two lobes of lactoferrin have different antimicrobial and antifungal properties. PRO K can digest hair (keratin). 3D structures of proteinaseUpdated on 16-April-2014 PRO A 2sga – SgPRO – Streptomyces griseus 2jxr, 1fmu, 1fmx – yPRO - yeast 1sgc - SgPRO + chymostatin A 3sga, 4sga, 5sga - SgPRO + polypeptide inhibitor 1dp5, 1dpj, 1g0v - yPRO + polypeptide inhibitor IA3 1fq5 - yPRO + inhibitor PRO B 3sgb – SgPRO + turkey ovomucoid inhibitor 1sgp, 1sgq, 1sgr, 1cso, 1ct0, 1ct2, 1ct4, 1ds2, 2sgp, 2nu3, 2nu4 – SgPRO + turkey ovomucoid inhibitor (mutant) 4sgb - SgPRO + potato inhibitor PRO K 2prk, 1cnm, 1egq, 2id8, 2g4v, 2v8b, 3gt3, 3gt4, 3d9q, 3ddz, 3de0 , 3de1, 3de2, 3de3, 3de4, 3de5, 3de6, 3de7, 3dvq, 3dvr, 3dvs, 3dw1, 3dw3, 3dwe, 3i2y, 3i30, 3i37, 3i34, 3l1k, 3aj8, 3aj9, 3q40, 3q5g, 3qmp, 4b5l, 4fon – EaPRO + Ca – Engyodontium album 1ic6 – EaPRO (mutant) + Ca PRO K complex with peptide 3prk, 1p7v, 1p7w – EaPRO + Ca + peptide inhibitor 1bjr, 2dqk, 2duj – EaPRO + Ca + lactoferrin peptide PRO K complex with small molecule 2pwb – EaPRO + Ca + coumarin 2pyz – EaPRO + Ca + auramine
PRO 3C 1qa7 – PRO – Hepatitis virus 2vb0 - PRO – Coxsakievirus H2-PRO 1wni – PRO – Trimeresurus flavoviridis Aspartic PRO 2asi – PRO – Rhizomucor miehei 1zap – CaPRO – Candida albicans 1izd - AoPRO – Aspergillus oryzae 1eag – CaPRO + inhibitor 1fq4 - yPRO + inhibitor 1j71 - PRO + polypeptide inhibitor – Candida tropicalis 1ize - AoPRO + polypeptide-statine inhibitor 1wkr - PRO + polypeptide-statine inhibitor – Irpex lacteus Cysteine PRO 2hrv – PRO 2A – human rhinovirus Serine PRO 1s2n, 1sh7 – PRO – Vibrio 3s9a, 3s9b – RvPRO – Siamese Russell’s viper 3s9c, 3sbk – RvPRO + human factor V polypeptide 1ga1, 1ga4, 1ga6, 1nlu – PsPRO + iodotyrostatin fragment – Pseudomonas 1kdv, 1kdy, 1kdz, 1ke1, 1ke2 - PsPRO + polypeptide inhibitor
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References
Proteopedia Page Contributors and Editors (what is this?)
Michal Harel, Joel L. Sussman, Alexander Berchansky, Karsten Theis
