4mpm

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Template:STRUCTURE 4mpm

Contents

Wild-type human neuroglobin

Template:ABSTRACT PUBMED 24699645

Function

[NGB_HUMAN] Involved in oxygen transport in the brain. Hexacoordinate globin, displaying competitive binding of oxygen or the distal His residue to the iron atom. Not capable of penetrating cell membranes. The deoxygenated form exhibits nitrite reductase activity inhibiting cellular respiration via NO-binding to cytochrome c oxidase. Involved in neuroprotection during oxidative stress. May exert its anti-apoptotic activity by acting to reset the trigger level of mitochondrial cytochrome c release necessary to commit the cells to apoptosis.[1] [2] [3] [4] [5]

About this Structure

4mpm is a 2 chain structure with sequence from Human. Full crystallographic information is available from OCA.

See Also

Reference

  • Guimaraes BG, Hamdane D, Lechauve C, Marden MC, Golinelli-Pimpaneau B. The crystal structure of wild-type human brain neuroglobin reveals flexibility of the disulfide bond that regulates oxygen affinity. Acta Crystallogr D Biol Crystallogr. 2014 Apr 1;70(Pt 4):1005-14. doi:, 10.1107/S1399004714000078. Epub 2014 Mar 19. PMID:24699645 doi:http://dx.doi.org/10.1107/S1399004714000078
  1. ↑ Burmester T, Weich B, Reinhardt S, Hankeln T. A vertebrate globin expressed in the brain. Nature. 2000 Sep 28;407(6803):520-3. PMID:11029004 doi:http://dx.doi.org/10.1038/35035093
  2. ↑ Dewilde S, Kiger L, Burmester T, Hankeln T, Baudin-Creuza V, Aerts T, Marden MC, Caubergs R, Moens L. Biochemical characterization and ligand binding properties of neuroglobin, a novel member of the globin family. J Biol Chem. 2001 Oct 19;276(42):38949-55. Epub 2001 Jul 25. PMID:11473128 doi:http://dx.doi.org/10.1074/jbc.M106438200
  3. ↑ Watanabe S, Wakasugi K. Zebrafish neuroglobin is a cell-membrane-penetrating globin. Biochemistry. 2008 May 13;47(19):5266-70. doi: 10.1021/bi800286m. Epub 2008 Apr, 17. PMID:18416560 doi:http://dx.doi.org/10.1021/bi800286m
  4. ↑ Brittain T, Skommer J, Henty K, Birch N, Raychaudhuri S. A role for human neuroglobin in apoptosis. IUBMB Life. 2010 Dec;62(12):878-85. doi: 10.1002/iub.405. PMID:21190290 doi:http://dx.doi.org/10.1002/iub.405
  5. ↑ Tiso M, Tejero J, Basu S, Azarov I, Wang X, Simplaceanu V, Frizzell S, Jayaraman T, Geary L, Shapiro C, Ho C, Shiva S, Kim-Shapiro DB, Gladwin MT. Human neuroglobin functions as a redox-regulated nitrite reductase. J Biol Chem. 2011 May 20;286(20):18277-89. doi: 10.1074/jbc.M110.159541. Epub, 2011 Feb 4. PMID:21296891 doi:http://dx.doi.org/10.1074/jbc.M110.159541

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