4np2

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Template:STRUCTURE 4np2

Contents 1 Crystal structure of the murine CD44 hyaluronan binding domain complex with a small molecule 2 Function 3 About this Structure 4 Reference

Crystal structure of the murine CD44 hyaluronan binding domain complex with a small molecule

Template:ABSTRACT PUBMED 24606063

Function

[CD44_MOUSE] Main cell surface receptor for hyaluronate. Adhesion to mucosal high endothelial venule and to types I and VI collagen. Probably involved in matrix adhesion, lymphocyte activation and lymph node homing.

About this Structure

4np2 is a 1 chain structure. Full crystallographic information is available from OCA.

Reference

• Liu LK, Finzel BC. Fragment-Based Identification of an Inducible Binding Site on Cell Surface Receptor CD44 for the Design of Protein-Carbohydrate Interaction Inhibitors. J Med Chem. 2014 Mar 27;57(6):2714-25. doi: 10.1021/jm5000276. Epub 2014 Mar 7. PMID:24606063 doi:http://dx.doi.org/10.1021/jm5000276