4oog

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Template:STRUCTURE 4oog

Contents

Crystal structure of yeast RNase III (Rnt1p) complexed with the product of dsRNA processing

Template:ABSTRACT PUBMED 24703949

Function

[RNT1_YEAST] DsRNA-specific nuclease that cleaves eukaryotic pre-ribosomal RNA at the U3 snoRNP-dependent A0 site in the 5'-external transcribed spacer (ETS) and in the 3'-ETS. In vitro, cleaves synthetic 5'-ETS RNA A0 site in the absence of snoRNA or other factors. Has an essential growth function in addition to pre-rRNA processing.

About this Structure

4oog is a 4 chain structure. Full crystallographic information is available from OCA.

Reference

  • Liang YH, Lavoie M, Comeau MA, Abou Elela S, Ji X. Structure of a Eukaryotic RNase III Postcleavage Complex Reveals a Double-Ruler Mechanism for Substrate Selection. Mol Cell. 2014 Apr 2. pii: S1097-2765(14)00211-1. doi:, 10.1016/j.molcel.2014.03.006. PMID:24703949 doi:http://dx.doi.org/10.1016/j.molcel.2014.03.006

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