4ci8

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Template:STRUCTURE 4ci8

Contents

Crystal structure of the tandem atypical beta-propeller domain of EML1

Template:ABSTRACT PUBMED 24706829

Function

[EMAL1_HUMAN] May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic (By similarity).

About this Structure

4ci8 is a 2 chain structure. Full crystallographic information is available from OCA.

Reference

  • Richards MW, Law EW, Rennalls LP, Busacca S, O'Regan L, Fry AM, Fennell DA, Bayliss R. Crystal structure of EML1 reveals the basis for Hsp90 dependence of oncogenic EML4-ALK by disruption of an atypical beta-propeller domain. Proc Natl Acad Sci U S A. 2014 Apr 8;111(14):5195-200. doi:, 10.1073/pnas.1322892111. Epub 2014 Mar 24. PMID:24706829 doi:http://dx.doi.org/10.1073/pnas.1322892111

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OCA

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