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4lg9

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Template:STRUCTURE 4lg9

Contents

Crystal structure of TBL1XR1 WD40 repeats

Function

[TBL1R_HUMAN] F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of the N-Cor corepressor complex that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of N-Cor complex, thereby allowing cofactor exchange, and transcription activation.[1]

About this Structure

4lg9 is a 1 chain structure. Full crystallographic information is available from OCA.

Reference

  1. ↑ Perissi V, Aggarwal A, Glass CK, Rose DW, Rosenfeld MG. A corepressor/coactivator exchange complex required for transcriptional activation by nuclear receptors and other regulated transcription factors. Cell. 2004 Feb 20;116(4):511-26. PMID:14980219

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OCA

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