1r6k

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Template:STRUCTURE 1r6k

Contents

HPV11 E2 TAD crystal structure

Template:ABSTRACT PUBMED 14634007

Function

[VE2_HPV11] E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication.

About this Structure

1r6k is a 1 chain structure with sequence from Human papillomavirus type 11. Full crystallographic information is available from OCA.

Reference

  • Wang Y, Coulombe R, Cameron DR, Thauvette L, Massariol MJ, Amon LM, Fink D, Titolo S, Welchner E, Yoakim C, Archambault J, White PW. Crystal structure of the E2 transactivation domain of human papillomavirus type 11 bound to a protein interaction inhibitor. J Biol Chem. 2004 Feb 20;279(8):6976-85. Epub 2003 Nov 22. PMID:14634007 doi:10.1074/jbc.M311376200

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