1jpv

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Template:STRUCTURE 1jpv

Contents

Crystal Structure of 5'-deoxy-5'-methylthioadenosine phosphorylase complexed with SO4

Template:ABSTRACT PUBMED 11489901

Function

[MTAP_SULSO] Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.[1]

About this Structure

1jpv is a 3 chain structure with sequence from Sulfolobus solfataricus. Full crystallographic information is available from OCA.

Reference

  • Appleby TC, Mathews II, Porcelli M, Cacciapuoti G, Ealick SE. Three-dimensional structure of a hyperthermophilic 5'-deoxy-5'-methylthioadenosine phosphorylase from Sulfolobus solfataricus. J Biol Chem. 2001 Oct 19;276(42):39232-42. Epub 2001 Aug 6. PMID:11489901 doi:http://dx.doi.org/10.1074/jbc.M105694200
  1. ↑ Cacciapuoti G, Forte S, Moretti MA, Brio A, Zappia V, Porcelli M. A novel hyperthermostable 5'-deoxy-5'-methylthioadenosine phosphorylase from the archaeon Sulfolobus solfataricus. FEBS J. 2005 Apr;272(8):1886-99. PMID:15819883 doi:http://dx.doi.org/10.1111/j.1742-4658.2005.04619.x

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