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3n09

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Template:STRUCTURE 3n09

Contents

Atomic model of an infectious rotavirus particle

Template:ABSTRACT PUBMED 21157433

Function

[VP6_ROTRH] Intermediate capsid protein that self assembles to form an icosahedral capsid with a T=13 symmetry, which consists of 230 trimers of VP6, with channels at each of its five-fold vertices. This capsid constitutes the middle concentric layer of the viral mature particle. The innermost VP2 capsid and the intermediate VP6 capsid remain intact following cell entry to protect the dsRNA from degradation and to prevent unfavorable antiviral responses in the host cell during all the replication cycle of the virus. Nacent transcripts are transcribed within the structural confines of this double-layered particle (DLP) and are extruded through the channels at the five-fold axes. VP6 is required for the transcription activity of the DLP (By similarity).

About this Structure

3n09 is a 15 chain structure with sequence from Rotrh and Simian rotavirus a strain rrv. Full crystallographic information is available from OCA.

Reference

  • Settembre EC, Chen JZ, Dormitzer PR, Grigorieff N, Harrison SC. Atomic model of an infectious rotavirus particle. EMBO J. 2011 Jan 19;30(2):408-16. Epub 2010 Dec 14. PMID:21157433 doi:10.1038/emboj.2010.322

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