This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
4pxt
From Proteopedia
Contents |
Structural basis for the assembly of the mitotic motor kinesin-5 into bipolar tetramers
Template:ABSTRACT PUBMED 24714498
Function
[KL61_DROME] Important role in mitotic dividing cells. Microtubule motor required for spindle body separation. Slow plus-end directed microtubule motor capable of cross-linking and sliding apart antiparallel microtubules, thereby pushing apart the associated spindle poles during spindle assembly and function.
About this Structure
4pxt is a 2 chain structure. Full crystallographic information is available from OCA.
Reference
- Scholey JE, Nithianantham S, Scholey JM, Al-Bassam J. Structural basis for the assembly of the mitotic motor Kinesin-5 into bipolar tetramers. Elife. 2014 Apr 8;3:e02217. doi: 10.7554/eLife.02217. PMID:24714498
Categories: Al-Bassam, J. | Nithianantham, S. | Scholey, J E. | Scholey, J M. | Anti-parallel four-helix bundle | Bipolar assembly domain of kinesin-5 | Bipolar tetramer | Cell cycle | Coiled-coil | Crosslinking adjacent microtubules into bundles throughout the mitotic spindle | Kinesin-5 functions via a sliding filament mechanism | Microtubule
