4pxt
From Proteopedia
Contents |
Structural basis for the assembly of the mitotic motor kinesin-5 into bipolar tetramers
Template:ABSTRACT PUBMED 24714498
Function
[KL61_DROME] Important role in mitotic dividing cells. Microtubule motor required for spindle body separation. Slow plus-end directed microtubule motor capable of cross-linking and sliding apart antiparallel microtubules, thereby pushing apart the associated spindle poles during spindle assembly and function.
About this Structure
4pxt is a 2 chain structure. Full crystallographic information is available from OCA.
Reference
- Scholey JE, Nithianantham S, Scholey JM, Al-Bassam J. Structural basis for the assembly of the mitotic motor Kinesin-5 into bipolar tetramers. Elife. 2014 Apr 8;3:e02217. doi: 10.7554/eLife.02217. PMID:24714498
Categories: Al-Bassam, J. | Nithianantham, S. | Scholey, J E. | Scholey, J M. | Anti-parallel four-helix bundle | Bipolar assembly domain of kinesin-5 | Bipolar tetramer | Cell cycle | Coiled-coil | Crosslinking adjacent microtubules into bundles throughout the mitotic spindle | Kinesin-5 functions via a sliding filament mechanism | Microtubule
