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Strictosidine Synthase

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Revision as of 21:28, 6 March 2008 by Santosh Panjikar (Talk | contribs)
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PDB ID 2fp8

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strictosidine synthase (EC 4.3.3.2) is an enzyme that catalyzes the chemical reaction 

   3-alpha(S)-strictosidine + H2O \rightleftharpoons tryptamine + secologanin

Thus, the two substrates of this enzyme are 3-alpha(S)-strictosidine and H2O, whereas its two products are tryptamine and secologanin.

This enzyme belongs to the family of lyases, specifically amine lyases, which cleave carbon-nitrogen bonds. The systematic name of this enzyme class is 3-alpha(S)-strictosidine tryptamine-lyase (secologanin-forming). Other names in common use include strictosidine synthetase, STR, and 3-alpha(S)-strictosidine tryptamine-lyase. This enzyme participates in terpenoid biosynthesis and indole and ipecac alkaloid biosynthesis.

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Michal Harel, Santosh Panjikar, Alexander Berchansky

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