4js9
From Proteopedia
Contents |
Structural Characterization of Inducible Nitric Oxide Synthase Substituted With Mesoheme
Function
[NOS2_MOUSE] Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such COX2.[1]
About this Structure
4js9 is a 2 chain structure. Full crystallographic information is available from OCA.
Reference
- ↑ Kim SF, Huri DA, Snyder SH. Inducible nitric oxide synthase binds, S-nitrosylates, and activates cyclooxygenase-2. Science. 2005 Dec 23;310(5756):1966-70. PMID:16373578 doi:http://dx.doi.org/10.1126/science.1119407
Categories: Bolisetty, K. | Hannibal, L. | Misra, S. | Page, R C. | Stuehr, D J. | Yu, Z. | Calmodulin-binding | Fad | Fmn | Iron | Mesoheme | Metal-binding | Nadp | Oxidoreductase