1vce

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Template:STRUCTURE 1vce

Contents

Crystal structure of project ID PH0725 from Pyrococcus horikoshii OT3

Function

[DPHB_PYRHO] S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.[1]

About this Structure

1vce is a 2 chain structure with sequence from Pyrococcus horikoshii. Full crystallographic information is available from OCA.

See Also

Reference

  1. ↑ Zhu X, Kim J, Su X, Lin H. Reconstitution of diphthine synthase activity in vitro. Biochemistry. 2010 Nov 9;49(44):9649-57. doi: 10.1021/bi100812h. PMID:20873788 doi:http://dx.doi.org/10.1021/bi100812h

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