1vbj

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Template:STRUCTURE 1vbj

Contents 1 The crystal structure of prostaglandin F synthase from Trypanosoma brucei 2 Function 3 About this Structure 4 See Also 5 Reference

The crystal structure of prostaglandin F synthase from Trypanosoma brucei

Function

[Q9GV41_9TRYP] Catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2. Has also aldo/ketoreductase activity towards the synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde.

About this Structure

1vbj is a 2 chain structure with sequence from Trypanosoma brucei. Full crystallographic information is available from OCA.

See Also

• Prostaglandin F synthase

Reference

• Kilunga KB, Inoue T, Okano Y, Kabututu Z, Martin SK, Lazarus M, Duszenko M, Sumii Y, Kusakari Y, Matsumura H, Kai Y, Sugiyama S, Inaka K, Inui T, Urade Y. Structural and mutational analysis of Trypanosoma brucei prostaglandin H2 reductase provides insight into the catalytic mechanism of aldo-ketoreductases. J Biol Chem. 2005 Jul 15;280(28):26371-82. Epub 2005 Apr 21. PMID:15845552 doi:10.1074/jbc.M413884200