1wwl

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Template:STRUCTURE 1wwl

Contents

Crystal structure of CD14

Template:ABSTRACT PUBMED 15644310

Function

[CD14_MOUSE] Cooperates with MD-2 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Up-regulates cell surface molecules, including adhesion molecules (By similarity).

About this Structure

1wwl is a 2 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

  • Kim JI, Lee CJ, Jin MS, Lee CH, Paik SG, Lee H, Lee JO. Crystal structure of CD14 and its implications for lipopolysaccharide signaling. J Biol Chem. 2005 Mar 25;280(12):11347-51. Epub 2005 Jan 10. PMID:15644310 doi:10.1074/jbc.M414607200

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