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2atb

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Template:STRUCTURE 2atb

Triple mutant 8D9D10V of scorpion toxin LQH-alpha-IT

Function

[SCXA_LEIQH] Alpha toxins bind voltage-independently at site-3 of sodium channels (Nav) and inhibit the inactivation of the activated channels, thereby blocking neuronal transmission. The dissociation is voltage-dependent. This toxin is active on insects. It is also highly toxic to crustaceans and has a measurable but low toxicity to mice.

About this Structure

2atb is a 2 chain structure with sequence from Leiurus quinquestriatus. Full crystallographic information is available from OCA.

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OCA

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