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1v6b

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Template:STRUCTURE 1v6b

Contents

Solution structure of the third PDZ domain of mouse harmonin

Function

[USH1C_MOUSE] Required for normal development and maintenance of cochlear hair cell bundles. Anchoring/scaffolding protein that is a part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing.[1]

About this Structure

1v6b is a 1 chain structure with sequence from Mus musculus. Full experimental information is available from OCA.

Reference

  1. ↑ Grillet N, Xiong W, Reynolds A, Kazmierczak P, Sato T, Lillo C, Dumont RA, Hintermann E, Sczaniecka A, Schwander M, Williams D, Kachar B, Gillespie PG, Muller U. Harmonin mutations cause mechanotransduction defects in cochlear hair cells. Neuron. 2009 May 14;62(3):375-87. doi: 10.1016/j.neuron.2009.04.006. PMID:19447093 doi:http://dx.doi.org/10.1016/j.neuron.2009.04.006

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