2hf6

From Proteopedia

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Template:STRUCTURE 2hf6

Contents 1 Solution structure of human zeta-COP 2 Function 3 About this Structure 4 Reference

Solution structure of human zeta-COP

Template:ABSTRACT PUBMED 19167404

Function

[COPZ1_HUMAN] The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity). The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex.

About this Structure

2hf6 is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

• Yu W, Lin J, Jin C, Xia B. Solution structure of human zeta-COP: direct evidences for structural similarity between COP I and clathrin-adaptor coats. J Mol Biol. 2009 Mar 6;386(4):903-12. Epub 2009 Jan 10. PMID:19167404 doi:10.1016/j.jmb.2008.12.083