2ch8

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Template:STRUCTURE 2ch8

Contents

STRUCTURE OF THE EPSTEIN-BARR VIRUS ONCOGENE BARF1

Template:ABSTRACT PUBMED 16647084

Function

[BRF1_EBV] Plays diverse functions in immunomodulation and oncogenicity, maybe by acting as a functional receptor for human CSF1. May inhibit interferon secretion from mononuclear cells. Exhibits oncogenic activity in vitro.[1] [2] [3]

About this Structure

2ch8 is a 4 chain structure with sequence from Human herpesvirus 4. Full crystallographic information is available from OCA.

Reference

  • Tarbouriech N, Ruggiero F, de Turenne-Tessier M, Ooka T, Burmeister WP. Structure of the Epstein-Barr virus oncogene BARF1. J Mol Biol. 2006 Jun 9;359(3):667-78. Epub 2006 Apr 18. PMID:16647084 doi:10.1016/j.jmb.2006.03.056
  1. ↑ Sall A, Caserta S, Jolicoeur P, Franqueville L, de Turenne-Tessier M, Ooka T. Mitogenic activity of Epstein-Barr virus-encoded BARF1 protein. Oncogene. 2004 Jun 17;23(28):4938-44. PMID:15064715 doi:10.1038/sj.onc.1207607
  2. ↑ Seto E, Yang L, Middeldorp J, Sheen TS, Chen JY, Fukayama M, Eizuru Y, Ooka T, Takada K. Epstein-Barr virus (EBV)-encoded BARF1 gene is expressed in nasopharyngeal carcinoma and EBV-associated gastric carcinoma tissues in the absence of lytic gene expression. J Med Virol. 2005 May;76(1):82-8. PMID:15778977 doi:10.1002/jmv.20327
  3. ↑ Wang Q, Tsao SW, Ooka T, Nicholls JM, Cheung HW, Fu S, Wong YC, Wang X. Anti-apoptotic role of BARF1 in gastric cancer cells. Cancer Lett. 2006 Jul 8;238(1):90-103. Epub 2005 Jul 27. PMID:16054293 doi:10.1016/j.canlet.2005.06.023

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