1ye6

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Template:STRUCTURE 1ye6

Contents 1 Crystal structure of the Lys-274 to Arg mutant of Candida tenuis xylose reductase (AKR2B5) bound to NADP+ 2 Function 3 About this Structure 4 Reference

Crystal structure of the Lys-274 to Arg mutant of Candida tenuis xylose reductase (AKR2B5) bound to NADP+

Template:ABSTRACT PUBMED 15670843

Function

[XYL1_CANTE] Reduces D-xylose into xylitol. Has a preference for NADPH, but can also utilize NADH as cosubstrate.

About this Structure

1ye6 is a 4 chain structure with sequence from Atcc 10573. Full crystallographic information is available from OCA.

Reference

• Leitgeb S, Petschacher B, Wilson DK, Nidetzky B. Fine tuning of coenzyme specificity in family 2 aldo-keto reductases revealed by crystal structures of the Lys-274-->Arg mutant of Candida tenuis xylose reductase (AKR2B5) bound to NAD+ and NADP+. FEBS Lett. 2005 Jan 31;579(3):763-7. PMID:15670843 doi:10.1016/j.febslet.2004.12.063