This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2c91

From Proteopedia

Revision as of 08:40, 23 April 2014 by OCA (Talk | contribs)
Jump to: navigation, search

Template:STRUCTURE 2c91

Contents

MOUSE SUCCINIC SEMIALDEHYDE REDUCTASE, AKR7A5

Template:ABSTRACT PUBMED 16460003

Function

[ARK72_MOUSE] Catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate. May have an important role in producing the neuromodulator gamma-hydroxybutyrate (GHB). Has broad substrate specificity. Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen (By similarity).[1]

About this Structure

2c91 is a 10 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

  • Zhu X, Lapthorn AJ, Ellis EM. Crystal structure of mouse succinic semialdehyde reductase AKR7A5: structural basis for substrate specificity. Biochemistry. 2006 Feb 14;45(6):1562-70. PMID:16460003 doi:10.1021/bi051610k
  1. ↑ Zhu X, Lapthorn AJ, Ellis EM. Crystal structure of mouse succinic semialdehyde reductase AKR7A5: structural basis for substrate specificity. Biochemistry. 2006 Feb 14;45(6):1562-70. PMID:16460003 doi:10.1021/bi051610k

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2c91"
Personal tools