2fj9

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Template:STRUCTURE 2fj9

Contents

High resolution crystal structure of the unliganded human ACBP

Template:ABSTRACT PUBMED 17044054

Function

[ACBP_HUMAN] Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters. It is also able to displace diazepam from the benzodiazepine (BZD) recognition site located on the GABA type A receptor. It is therefore possible that this protein also acts as a neuropeptide to modulate the action of the GABA receptor.

About this Structure

2fj9 is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Taskinen JP, van Aalten DM, Knudsen J, Wierenga RK. High resolution crystal structures of unliganded and liganded human liver ACBP reveal a new mode of binding for the acyl-CoA ligand. Proteins. 2007 Jan 1;66(1):229-38. PMID:17044054 doi:10.1002/prot.21124

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