1tjx

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Template:STRUCTURE 1tjx

Contents

Crystallographic Identification of Ca2+ Coordination Sites in Synaptotagmin I C2B Domain

Template:ABSTRACT PUBMED 15340165

Function

[SYT1_RAT] May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2.

About this Structure

1tjx is a 1 chain structure with sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

  • Cheng Y, Sequeira SM, Malinina L, Tereshko V, Sollner TH, Patel DJ. Crystallographic identification of Ca2+ and Sr2+ coordination sites in synaptotagmin I C2B domain. Protein Sci. 2004 Oct;13(10):2665-72. Epub 2004 Aug 31. PMID:15340165 doi:10.1110/ps.04832604

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