2b0u
From Proteopedia
Contents |
The Structure of the Follistatin:Activin Complex
Template:ABSTRACT PUBMED 16198295
Function
[INHBA_HUMAN] Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins. [FST_HUMAN] Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH).
About this Structure
2b0u is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Thompson TB, Lerch TF, Cook RW, Woodruff TK, Jardetzky TS. The structure of the follistatin:activin complex reveals antagonism of both type I and type II receptor binding. Dev Cell. 2005 Oct;9(4):535-43. PMID:16198295 doi:http://dx.doi.org/10.1016/j.devcel.2005.09.008
