Ribosomal protein L7/L12

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Image:1dd3.png
Crystal Structure of Ribosomal protein L7/L12 from Thermotoga maritima (1dd3)

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Ribosomal protein L7 (RPL7) is one of the 34 proteins which belong to the large 50S subunit of the prokaryotic ribosome or to the ca. 49 proteins in the large 60S subunit of the eukaryotic ribosome. It is part of the L7/L12 complex. Two dimers of L7/L12 are present in the large subunit. The L7/L12 probably interacts with EF-Tu. L7 and L12 differ by one post-translational modification at the N-terminal of L7. In the archaea, the L7Ae acts as a subunit of RNase P.

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3D Structures of Ribosomal protein L7

Updated on 24-April-2014

RPL7

1rqu, 1rqv - EcRPL7 - Escherichia coli - NMR
1dd3, 1dd4 - TmRPL7/L12 - Thermotoga maritima
1rqs – EcRPL7/L12 - NMR
1rqt - EcRPL7/L12 N-terminal – NMR
1ctf - EcRPL7/L12 C-terminal
3paf - MjRPL7Ae (mutant)
1ra4, 1xbi – MjRPL7Ae – Methasnocaldococcus jannaschii
1sds – MjRPL7Ae+box H/ACA RNA
2fc3 – RPL7Ae – Aeropyrum pernix
2czw – RPL7Ae – Pyrococcus horikoshii
1pxw - RPL7Ae – Pyrococcus abyssi
1rlg – RPL7Ae+RNA fragment – Archaeoglobus fulgidus
3pla - RPL7Ae + pre mRNA splicing protein + fibrillarin-like methyltransferase + RNA - Sulfolobus solfataricus
3o85 - RPL7Ae – Giardia lamblia
3nvi – PfRPL7Ae + NOP5/NOP56 + RNA – Pyrococcus furiosus
3nvk – PfRPL7Ae + NOP5/NOP56 + fibrillarin-like methyltransferase + RNA

L7 in part of 50S subunit

2bcw – EcRPL7/L12+EcRPL11+EF-G
1zav, 1zaw, 1zax - TmRPL7/L12 N-terminal +RPL10

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Michal Harel, Alexander Berchansky, Joel L. Sussman, Jaime Prilusky

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