Neprilysin (NEP), also known as neutral endopeptidase, is a Zn-dependent metalloprotease which degrades small secreted peptides like the beta-amyloid peptide, tachykinin, neurotensin and enkephalins.[1][2][3][4][5][6][7][8] Its signalling has also been implicated in cardiovascular disease.[9] NEP turns off peptide signalling events at the cell surface. NEP is found in brain tissue and is an integral membrane protein.
3D structures of neprilysin
1dmt – hNEP extracellular domain + phosphoramidon – human
1r1h, 1r1i, 1r1j, 1y8j, 2qpj, 2yb9 - hNEP extracellular domain + inhibitor
2yvc – NEP cytoplasmic tail + radixin - mouse
