Sandbox Reserved 931

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This Sandbox is Reserved from 01/04/2014, through 30/06/2014 for use in the course "510042. Protein structure, function and folding" taught by Prof Adrian Goldman, Tommi Kajander, Taru Meri, Konstantin Kogan and Juho Kellosalo at the University of Helsinki. This reservation includes Sandbox Reserved 923 through Sandbox Reserved 947.

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Contents 1 LINE-1 ORF1 Protein 2 Introduction 2.1 Stabilization of the Trimeric Structure 3 A Cool Movie

LINE-1 ORF1 Protein

Long interspersed element 1 (LINE1) open reading frame 1 (L1ORF1) is a LINE-type retrotransposon (class I-transposon) in humans that is responsible for retrotransposition - a process increasing the DNA variety and size of the genome. The protein localizes to large L1 ribonucleoprotein particles, stress granules and nucleus (ref).

Introduction

During retrotransposition, the RNA transcript is reversely transcribed to DNA and integrated with the genome in different place than the original gene. The process is catalyzed by retrotransposons, which often integrate reverse transcriptase and endonuclease functions required in the process.

       L1ORF1 localizes to ribonuclein particles, stress granules and nucleus. Although the protein has general affinity to nucleic acids, it displays a strong cis preference, what makes it bind primarily encoding RNA transcripts (ref). In a process known as target-primed reverse transcription, L1ORF1 reversely transcribes the mRNA at the point of genomic integration (ref) and assists with the integration with the DNA.

Stabilization of the Trimeric Structure

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A Cool Movie

["http://www.nature.com/nsmb/journal/v18/n9/extref/nsmb.2097-S2.mov"|Click]