16vp
From Proteopedia
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CONSERVED CORE OF THE HERPES SIMPLEX VIRUS TRANSCRIPTIONAL REGULATORY PROTEIN VP16
Overview
On infection, the herpes simplex virus (HSV) virion protein VP16 (Vmw65; alphaTIF) forms a transcriptional regulatory complex-the VP16-induced complex-with two cellular proteins, HCF and Oct-1, on VP16-responsive cis-regulatory elements in HSV immediate-early promoters called TAATGARAT. Comparison of different HSV VP16 sequences reveals a conserved core region that is sufficient for VP16-induced complex formation. The crystal structure of the VP16 core has been determined at 2.1 A resolution. The results reveal a novel, seat-like protein structure. Together with the activity of mutant VP16 proteins, the structure of free VP16 suggests that it contains (1) a disordered carboxy-terminal region that associates with HCF, Oct-1, and DNA in the VP16-induced complex, and (2) a structured region involved in virion assembly and possessing a novel DNA-binding surface that differentiates among TAATGARAT VP16-response elements.
About this Structure
16VP is a Single protein structure of sequence from Human herpesvirus 6. Full crystallographic information is available from OCA.
Reference
Crystal structure of the conserved core of the herpes simplex virus transcriptional regulatory protein VP16., Liu Y, Gong W, Huang CC, Herr W, Cheng X, Genes Dev. 1999 Jul 1;13(13):1692-703. PMID:10398682
Page seeded by OCA on Thu Mar 20 09:50:11 2008
