176d

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spinqualitylabelsall models PDB ID 176d Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image
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NMR SOLUTION STRUCTURE OF A PEPTIDE NUCLEIC ACID COMPLEXED WITH RNA

Overview

Peptide nucleic acids (PNA) incorporating nucleic acid bases into an achiral polyamide backbone bind to DNA in a sequence-dependent manner. The structure of a PNA-ribonucleic acid (RNA) complex was determined with nuclear magnetic resonance methods. A hexameric PNA formed a 1:1 complex with a complementary RNA that is an antiparallel, right-handed double helix with Watson-Crick base pairing similar to the "A" form structure of RNA duplexes. The achiral PNA backbone assumed a distinct conformation upon binding that differed from previously proposed models and provides a basis for further structure-based design of antisense agents.

About this Structure

176D is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.

Reference

NMR solution structure of a peptide nucleic acid complexed with RNA., Brown SC, Thomson SA, Veal JM, Davis DG, Science. 1994 Aug 5;265(5173):777-80. PMID:7519361

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