Thiolase
From Proteopedia
Two different classes of thiolases are found . Degrative thiolase like 3-ketoacyl-CoA thiolase (KCT) is involved in fatty acid β oxidation. Biosynthetic thiolases like acetoacetyl-CoA thiolase (ACT) are involved in the thiolysis of acetoacetyl-CoA.
For Bacterial Thiolase see Bacterial thiolase
3D Structures of Thiolase
Updated on 18-May-2014
3-ketoacyl-CoA thiolase
2wu9, 2c7y, 2c7z – KCT peroxisomal residues 36-462 – Arabidopsis thaliana
2wua - KCT peroxisomal residues 17-449 (mutant) – sunflower
2iik – hKCT peroximal - human
3goa – KCT – Salmonella typhimurium
1afw, 1pxt – yKCT peroxisomal - yeast
3w15 - yKCT peroxisomal residues 27-396 + peroxiomal membrane protein PEX21 + peroxisomal targeting signal receptor
2d3t – PfKCT + fatty oxidation complex β subunit – Pseudomonas fragi
1wdk, 1wdl, 1wdm - PfKCT + fatty oxidation complex α subunit
Acetoacetyl-CoA thiolase
1m4s, 1m4t, 1dlu, 1qfl - ZrACT – Zoogloea ramigera
1dm3, 1dlv – ZrACT + CoA
2wku, 2wl6, 1m1t, 1m3k - ZrACT (mutant)
2wkt, 2wkv, 2wl4, 2wl5, 2vtz, 2vu0, 1m3z – ZrACT (mutant) + CoA
1m1o - ZrACT (mutant) + acetoacetyl-CoA
2vu0, 1nl7 - ZrACT + CoA
2vu1, 2vu2, 1ou6 - ZrACT + pantheteine-11-pivalate
2ib7, 2ib8, 2ib9, 2ibu, 2ibw, 2iby, 2f2s – hACT mitochondrial
1wl5 - hACT cytosolic
1wl4 – hACT cytosolic + CoA
4dd5, 4e1l – ACT – Clostridium difficile
