1a7x

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Image:1a7x.gif


PDB ID 1a7x

Drag the structure with the mouse to rotate
, resolution 2.0Å
Ligands:
Activity: Peptidylprolyl isomerase, with EC number 5.2.1.8
Coordinates: save as pdb, mmCIF, xml



FKBP12-FK1012 COMPLEX


Overview

A ligand that simultaneously binds two proteins must have two high affinity protein binding domains joined in a fashion that facilitates, or at least does not prevent, protein-protein interaction. Designing such ligands is challenging, and a high resolution X-ray structure of FKBP12-FK1012A-FKBP12 illustrates the subtleties of one successful design.

About this Structure

1A7X is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Chemical inducers of dimerization: the atomic structure of FKBP12-FK1012A-FKBP12., Schultz LW, Clardy J, Bioorg Med Chem Lett. 1998 Jan 6;8(1):1-6. PMID:9871618

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