2c4n
From Proteopedia
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NAGD FROM E.COLI K-12 STRAIN
Overview
The HAD superfamily is a large superfamily of proteins which share a, conserved core domain that provides those active site residues responsible, for the chemistry common to all family members. The superfamily is further, divided into the four subfamilies I, IIA, IIB, and III, based on the, topology and insertion site of a cap domain that provides substrate, specificity. This structural and functional division implies that members, of a given HAD structural subclass may target substrates that have similar, structural characteristics. To understand the structure/function, relationships in all of the subfamilies, a type IIA subfamily member, NagD, from Escherichia coli K-12, was selected (type I, IIB, and III members, have been more extensively studied). The structure of the NagD protein ... [(full description)]
About this Structure
2C4N is a [Single protein] structure of sequence from [Escherichia coli] with MG and PO4 as [ligands]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
Structure and activity analyses of Escherichia coli K-12 NagD provide insight into the evolution of biochemical function in the haloalkanoic acid dehalogenase superfamily., Tremblay LW, Dunaway-Mariano D, Allen KN, Biochemistry. 2006 Jan 31;45(4):1183-93. PMID:16430214
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