| Structural highlights
3rin is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
| | Ligands: |
| | Gene: | CSBP, CSBP1, CSBP2, CSPB1, MAPK14, MXI2 (Homo sapiens) |
| Activity: | Mitogen-activated protein kinase, with EC number 2.7.11.24 |
| Resources: | FirstGlance, OCA, RCSB, PDBsum |
Publication Abstract from PubMed
The use of structure-based design and molecular modeling led to the discovery of indolin-2-one derivatives as potent and selective p38alpha inhibitors. The predicted binding mode was confirmed by X-ray crystallography.
Indolin-2-one p38alpha inhibitors I: design, profiling and crystallographic binding mode.,Eastwood P, Gonzalez J, Gomez E, Vidal B, Caturla F, Roca R, Balague C, Orellana A, Dominguez M Bioorg Med Chem Lett. 2011 Jul 15;21(14):4130-3. Epub 2011 Jun 6. PMID:21696951[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
See Also
References
- ↑ Eastwood P, Gonzalez J, Gomez E, Vidal B, Caturla F, Roca R, Balague C, Orellana A, Dominguez M. Indolin-2-one p38alpha inhibitors I: design, profiling and crystallographic binding mode. Bioorg Med Chem Lett. 2011 Jul 15;21(14):4130-3. Epub 2011 Jun 6. PMID:21696951 doi:10.1016/j.bmcl.2011.05.114
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