Using structural insight, the binding mode of isofagomine-derived inhibitors with family GH9 glycosidases is achieved via the study of Alicyclobacillus acidocaldarius (AaCel9A) endoglucanase. In contrast to what was observed in the first report using these compounds with inverting glycosidases from family GH6, these inhibitors do not adopt a distorted conformation in the active site.
A potential fortuitous binding of inhibitors of an inverting family GH9 beta-glycosidase derived from isofagomine.,Morera S, Vigouroux A, Stubbs KA Org Biomol Chem. 2011 Sep 7;9(17):5945-7. Epub 2011 Jul 25. PMID:21785782[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
↑ Morera S, Vigouroux A, Stubbs KA. A potential fortuitous binding of inhibitors of an inverting family GH9 beta-glycosidase derived from isofagomine. Org Biomol Chem. 2011 Sep 7;9(17):5945-7. Epub 2011 Jul 25. PMID:21785782 doi:10.1039/c1ob05766a
