| Structural highlights
3zrm is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
| | Ligands: | , ,
| | NonStd Res: | |
| Related: | 2uw9, 1o6k, 1h8f, 1gng, 1q3w, 3zrk, 1i09, 2x37, 1o9u, 1o6l, 2jdr, 1j1b, 1r0e, 1q41, 2x39, 1q3d, 2jld, 1q5k, 2jdo, 1pyx, 1q4l, 1j1c, 2xh5, 1uv5, 3zrl |
| Activity: | [Tau_protein_kinase [Tau protein] kinase], with EC number 2.7.11.26 |
| Resources: | FirstGlance, OCA, RCSB, PDBsum |
Publication Abstract from PubMed
The discovery of a novel series of 2-(4-pyridyl)thienopyridinone GSK-3beta inhibitors is reported. X-ray crystallography reveals its binding mode and enables rationalization of the SAR. The initial optimization of the template for improved cellular activity and predicted CNS penetration is also presented.
Identification of 2-(4-pyridyl)thienopyridinones as GSK-3beta inhibitors.,Gentile G, Bernasconi G, Pozzan A, Merlo G, Marzorati P, Bamborough P, Bax B, Bridges A, Brough C, Carter P, Cutler G, Neu M, Takada M Bioorg Med Chem Lett. 2011 Aug 15;21(16):4823-7. Epub 2011 Jun 29. PMID:21764580[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
See Also
References
- ↑ Gentile G, Bernasconi G, Pozzan A, Merlo G, Marzorati P, Bamborough P, Bax B, Bridges A, Brough C, Carter P, Cutler G, Neu M, Takada M. Identification of 2-(4-pyridyl)thienopyridinones as GSK-3beta inhibitors. Bioorg Med Chem Lett. 2011 Aug 15;21(16):4823-7. Epub 2011 Jun 29. PMID:21764580 doi:10.1016/j.bmcl.2011.06.050
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