Publication Abstract from PubMed
A series of aminopyrazines as inhibitors of Syk kinase activity and showing inhibition of LAD2 cells degranulation is described. Optimization of the carboxamide motif with aminomethylpiperidines provided high potency inhibiting Syk but low cellular activity. Amides of cis and trans adamantanol showed good inhibitory activity against Syk as well as remarkable activity in LAD2 cells degranulation assay.
Pyrazine-based Syk kinase inhibitors.,Forns P, Esteve C, Taboada L, Alonso JA, Orellana A, Maldonado M, Carreno C, Ramis I, Lopez M, Miralpeix M, Vidal B Bioorg Med Chem Lett. 2012 Apr 15;22(8):2784-8. Epub 2012 Mar 2. PMID:22425453[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
