| Structural highlights
4afj is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
| | Ligands: | , ,
| | NonStd Res: | |
| Related: | 2uw9, 1o6k, 1gng, 1h8f, 1q3w, 3zrk, 1i09, 1o9u, 2x37, 3zrm, 4acg, 2jdr, 1o6l, 1j1b, 1r0e, 1q41, 2x39, 4ach, 3zrl, 2jld, 1q3d, 4acc, 1q5k, 2jdo, 4acd, 1pyx, 1q4l, 1j1c, 1uv5, 2xh5 |
| Resources: | FirstGlance, OCA, RCSB, PDBsum |
Publication Abstract from PubMed
5-Aryl-4-carboxamide-1,3-oxazoles are a novel, potent and selective series of GSK-3 inhibitors. The optimization of the series to yield compounds with cell activity and brain permeability is described.
5-Aryl-4-carboxamide-1,3-oxazoles: Potent and selective GSK-3 inhibitors.,Gentile G, Merlo G, Pozzan A, Bernasconi G, Bax B, Bamborough P, Bridges A, Carter P, Neu M, Yao G, Brough C, Cutler G, Coffin A, Belyanskaya S Bioorg Med Chem Lett. 2012 Mar 1;22(5):1989-94. Epub 2012 Jan 21. PMID:22310227[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
See Also
References
- ↑ Gentile G, Merlo G, Pozzan A, Bernasconi G, Bax B, Bamborough P, Bridges A, Carter P, Neu M, Yao G, Brough C, Cutler G, Coffin A, Belyanskaya S. 5-Aryl-4-carboxamide-1,3-oxazoles: Potent and selective GSK-3 inhibitors. Bioorg Med Chem Lett. 2012 Mar 1;22(5):1989-94. Epub 2012 Jan 21. PMID:22310227 doi:10.1016/j.bmcl.2012.01.034
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