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1bgw

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Revision as of 08:10, 20 March 2008 by OCA (Talk | contribs)
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Image:1bgw.gif


PDB ID 1bgw

Drag the structure with the mouse to rotate
, resolution 2.7Å
Coordinates: save as pdb, mmCIF, xml



TOPOISOMERASE RESIDUES 410-1202,


Overview

The crystal structure of a large fragment of yeast type II DNA topoisomerase reveals a heart-shaped dimeric protein with a large central hole. It provides a molecular model of the enzyme as an ATP-modulated clamp with two sets of jaws at opposite ends, connected by multiple joints. An enzyme with bound DNA can admit a second DNA duplex through one set of jaws, transport it through the cleaved first duplex, and expel it through the other set of jaws.

About this Structure

1BGW is a Single protein structure of sequence from Saccharomyces cerevisiae. The following page contains interesting information on the relation of 1BGW with [Topoisomerases]. Full crystallographic information is available from OCA.

Reference

Structure and mechanism of DNA topoisomerase II., Berger JM, Gamblin SJ, Harrison SC, Wang JC, Nature. 1996 Jan 18;379(6562):225-32. PMID:8538787

Page seeded by OCA on Thu Mar 20 10:10:54 2008

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