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Poly(dA).poly(dT) has unusual properties in that it cannot associate into nucleosomes and short, phased runs of it cause DNA bending. The crystal structure of a B-type DNA dodecamer containing a homopolymeric run of six A.T base pairs shows that this region possesses special structural features, including a system of bifurcated hydrogen bonds, which explains some of the properties of this simple homopolymer.
The structure of an oligo(dA).oligo(dT) tract and its biological implications.,Nelson HC, Finch JT, Luisi BF, Klug A Nature. 1987 Nov 19-25;330(6145):221-6. PMID:3670410[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
↑ Nelson HC, Finch JT, Luisi BF, Klug A. The structure of an oligo(dA).oligo(dT) tract and its biological implications. Nature. 1987 Nov 19-25;330(6145):221-6. PMID:3670410 doi:http://dx.doi.org/10.1038/330221a0
