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The crystal structure of the self-complementary DNA octamer d(GGCATGCC) has been determined to a resolution of 2.38 A and R factor of 17.1%. The structure is an A-DNA octamer duplex with Watson-Crick base pairing along its length. This sequence extends the investigation of octamer duplexes of the type d(GGX(4)CC) which assume P6(1) packing within the crystallographic unit cell. The A-DNA duplex is non-linear with a helix axis curvature of 7 degrees and bending towards the DNA minor groove. In view of the biological importance of protein recognition of some A-DNA sequences the minor-groove geometry and helix-axis curvature for this structure is compared with all others of the type d(GGXATXCC).
Structure of the A-DNA octamer d(GGCATGCC).,Nunn CM, Neidle S Acta Crystallogr D Biol Crystallogr. 1997 May 1;53(Pt 3):269-73. PMID:15299929[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
↑ Nunn CM, Neidle S. Structure of the A-DNA octamer d(GGCATGCC). Acta Crystallogr D Biol Crystallogr. 1997 May 1;53(Pt 3):269-73. PMID:15299929 doi:10.1107/S0907444996014795
