Function
Succinate-semialdehyde dehydrogenase (SSD) catalyzes the conversion of succinate semialdehyde, NAD+ and water to succinate, NADH and H+. SSD participates in glutamate and butyrate metabolism.
Disease
SSD deficiency.
Relevance
Structural highlights
3D structures of succinate-semialdehyde dehydrogenase
Updated on 09-June-2014
4it9, 3vz1 – SySSD - Synechococcus
3vz2 – SySSD (mutant)
3ifg, 3ifh – SSD – Burkholderia pseudomallei
3rh9 – SSD – Marinobacter aquaeolei
2w8n, 2w8o – hSSD - human
2w8p – hSSD (mutant)
Succinate-semialdehyde dehydrogenase complexes
2w8q – hSSD (mutant) + succinate
2w8r – hSSD (mutant) + ADP
4ita – SySSD + NADPH
4itb – SySSD + NADPH + succinic semialdehyde
3vz3 – SySSD (mutant) + NADPH + succinic semialdehyde
3jz4 – SSD + NADPH – Escherichia coli
References
