Template:STRUCTURE 4k97
Function
Cyclic GMP-AMP synthase (CGAS) binds to DNA and catalyzes cGAMP synthesis. The cGAMP activates the type-I interferon pathway.
Disease
Mice lacking CGAS are more vulnerable to lethal infection by DNA virus.
Relevance
Structural highlights
3D structures of cyclic GMP-AMP synthase
Updated on 12-June-2014
4k8v – mCGAS C terminal – mouse
4km5, 4mkp, 4lev, 4lew, 4o68, 4o69 – hCGAS C terminal – human
4jlx – pCGAS C terminal – pig
Cyclic GMP-AMP synthase complex
4k96, 4ley, 4lez, 4o6a – mCGAS C terminal + DNA
4k97 – mCGAS C terminal + DNA + ATP
4k98, 4k99, 4k9a, 4k9b – mCGAS C terminal + DNA + polynucleotide
4kb6 – pCGAS C terminal + DNA + ATP + GTP
4jlz – pCGAS C terminal + UTP
4o67 - hCGAS C terminal + cyclic GMP-AMP
References