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4of5 is a 2 chain structure with sequence from Human. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
A recent paper by Sirois et al. in The Journal of Experimental Medicine reports that the receptor for advanced glycation end-products (RAGE) promotes uptake of DNA into endosomes and lowers the immune recognition threshold for the activation of Toll-like receptor 9. Two crystal structures suggested that the DNA phosphate-deoxyribose backbone is recognized by RAGE through well-defined interactions. However, the electron densities for the DNA molecules are weak enough that the presented modeling of DNA is questionable, and models only containing RAGE account for the observed diffraction data just as well as the RAGE-DNA complexes presented by the authors.
The specificity of DNA recognition by the RAGE receptor.,Yatime L, Andersen GR J Exp Med. 2014 May 5;211(5):749-50. doi: 10.1084/jem.20132526. Epub 2014 Apr 28. PMID:24778420[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
↑ Yatime L, Andersen GR. The specificity of DNA recognition by the RAGE receptor. J Exp Med. 2014 May 5;211(5):749-50. doi: 10.1084/jem.20132526. Epub 2014 Apr 28. PMID:24778420 doi:http://dx.doi.org/10.1084/jem.20132526
